Top Grossing Comedy Movies in Week 45 of 2010
| Rank | Title | Language | Domestic | Worldwide |
|---|---|---|---|---|
| 1 | Megamind |  KR | $148,415,853 | $321,885,765 |
| 2 | Due Date |  EN | $100,539,043 | $211,780,824 |
| 3 | Love & Other Drugs | EN | $32,367,005 | $102,820,008 |
| 4 | Four Lions | EN | $304,616 | $6,149,356 |
| 5 | Action Replayy |  IN | - | $5,702,135 |
| 6 | Saint |  NL | - | $3,797,890 |
| 7 | Romantic Debtors | KR | - | $3,121,099 |
| 8 | My Sassy Girl 2 |  CN | - | $2,776,022 |
| 9 | Golmaal 3 | IN | $1,132,192 | $2,067,671 |
| 10 | Flying Pigs |  PL | - | $1,898,456 |
| 11 | Vay Arkadaş |  TR | - | $1,550,505 |
| 12 | The Holy Man 3 |  TH | - | $1,205,719 |
| 13 | Pak Panter | TR | - | $766,048 |
| 14 | H2-Oh! | TH | - | $639,567 |
| 15 | Violet Tendencies | EN | $13,304 | $13,304 |
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