Top Grossing Comedy Movies in Week 21 of 2010
| Rank | Title | Language | Domestic | Worldwide |
|---|---|---|---|---|
| 1 | Shrek Forever After |  EN | $238,736,787 | $752,600,867 |
| 2 | Win/Win | EN | $10,179,275 | $11,789,613 |
| 3 | MacGruber | EN | $8,525,600 | $9,322,895 |
| 4 | Solitary Man | EN | $4,360,548 | $5,682,554 |
| 5 | Regresa |  ES | - | $1,461,942 |
| 6 | The Best Things in the World |  PT | - | $1,220,116 |
| 7 | The Two Deaths of Quincas Wateryell | PT | - | $1,212,639 |
| 8 | Once a Gangster | - | $1,052,022 | |
| 9 | Sam Yan |  TH | - | $793,905 |
| 10 | Permanent Nobara |  JP | - | $321,914 |
| 11 | A Distant Neighborhood |  FR | - | $231,820 |
| 12 | Perrier's Bounty | EN | $828 | $167,938 |
| 13 | Zenitram | ES | - | $20,600 |
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