Top Grossing Mystery Movies in 2001
| Rank | Title | Language | Domestic | Worldwide |
|---|---|---|---|---|
| 1 | Harry Potter and the Sorcerer's Stone |  EN | $318,886,962 | $1,026,517,806 |
| 2 | The Others | EN | $96,578,502 | $210,002,906 |
| 3 | Vanilla Sky | EN | $100,618,344 | $203,388,341 |
| 4 | Along Came a Spider | EN | $74,078,174 | $105,178,561 |
| 5 | Gosford Park | EN | $41,308,615 | $87,754,044 |
| 6 | From Hell | EN | $31,602,566 | $74,558,115 |
| 7 | Thirteen Ghosts | EN | $41,867,960 | $68,467,960 |
| 8 | K-PAX | EN | $50,338,485 | $65,001,485 |
| 9 | The Crimson Rivers |  FR | $594,966 | $60,103,680 |
| 10 | Jeepers Creepers | EN | $37,904,175 | $59,371,303 |
| 11 | Domestic Disturbance | EN | $45,246,095 | $54,249,294 |
| 12 | Recess: School's Out | EN | $36,706,141 | $44,460,850 |
| 13 | Memento | EN | $25,544,867 | $40,047,236 |
| 14 | Original Sin |  ES | $16,534,221 | $35,402,320 |
| 15 | Joe Dirt | EN | $27,087,695 | $30,987,695 |
| 16 | Hearts in Atlantis | EN | $24,185,781 | $30,919,415 |
| 17 | The Pledge | EN | $19,733,089 | $29,419,291 |
| 18 | Mulholland Dr. | EN | $7,220,243 | $20,391,793 |
| 19 | The Curse of the Jade Scorpion | EN | $7,517,191 | $18,914,307 |
| 20 | The Girl | EN | $14,018,296 | $16,860,964 |
| 21 | Lantana | EN | $4,623,189 | $15,747,450 |
| 22 | Vidocq | FR | - | $13,240,767 |
| 23 | Head Over Heels | EN | $10,424,470 | $13,127,022 |
| 24 | The Deep End | EN | $8,823,109 | $10,031,529 |
| 25 | Donnie Darko | EN | $1,478,493 | $7,415,552 |
| 26 | The Devil's Backbone | ES | $755,249 | $6,582,065 |
| 27 | Under the Sand | FR | $1,452,698 | $6,531,687 |
| 28 | Soul Survivors | EN | $3,111,545 | $4,299,141 |
| 29 | Waking Life | EN | $2,901,447 | $3,176,880 |
| 30 | Belphegor, Phantom of the Louvre | FR | - | $2,863,896 |
| 31 | Session 9 | EN | $378,176 | $1,612,259 |
| 32 | Brigham City | EN | $852,206 | $852,206 |
| 33 | The Caveman's Valentine | EN | $687,194 | $794,481 |
| 34 | Sleepless |  IT | - | $159,059 |
| 35 | Vampire Hunter D |  JP | $151,086 | $152,239 |
| 36 | Dancing at the Blue Iguana | EN | $67,913 | $122,121 |
| 37 | The Million Dollar Hotel | EN | $59,989 | $105,983 |
| 38 | Werckmeister Harmonies | $69,923 | $69,923 | |
| 39 | Kat |  DK | - | $67,035 |
| 40 | Children’s Play | FR | - | $61,230 |
| 41 | Visible Secret | - | $40,809 | |
| 42 | Tangled | EN | - | $38,407 |
| 43 | Tempted | EN | - | $30,295 |
| 44 | Proximity | FR | - | $18,569 |
| 45 | The Monkey's Mask | EN | - | $6,831 |
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