Top Grossing Mystery Movies in 2010
| Rank | Title | Language | Domestic | Worldwide |
|---|---|---|---|---|
| 1 | Harry Potter and the Deathly Hallows: Part I |  EN | $296,374,621 | $1,043,795,789 |
| 2 | Inception | EN | $292,587,330 | $839,381,898 |
| 3 | Shutter Island | EN | $128,012,934 | $294,978,537 |
| 4 | Salt |  IN | $118,311,368 | $293,503,354 |
| 5 | The Girl with the Dragon Tattoo |  SE | $102,515,793 | $232,617,430 |
| 6 | Paranormal Activity 2 | EN | $84,752,907 | $177,512,032 |
| 7 | Saw 3D | $45,710,178 | $136,151,680 | |
| 8 | A Nightmare on Elm Street | EN | $63,075,011 | $115,695,418 |
| 9 | Bestseller |  KR | - | $68,813,389 |
| 10 | The Girl Who Played with Fire | SE | $7,638,241 | $67,153,225 |
| 11 | Devil | EN | $33,601,190 | $62,695,489 |
| 12 | The Ghost Writer | EN | $15,541,549 | $60,331,447 |
| 13 | The Crazies | EN | $39,123,589 | $54,806,823 |
| 14 | Confessions |  JP | - | $45,203,103 |
| 15 | Detective Conan: The Lost Ship in the Sky | JP | - | $36,407,407 |
| 16 | The Secret in Their Eyes |  ES | $6,391,436 | $35,079,650 |
| 17 | The Extraordinary Adventures of Adèle Blanc-Sec |  FR | - | $34,604,339 |
| 18 | The Losers |  CN | $23,591,432 | $29,397,654 |
| 19 | Case 39 | EN | $13,261,851 | $28,190,603 |
| 20 | Let Me In | EN | $12,134,935 | $27,093,592 |
| 21 | Liar Game: The Final Stage | JP | - | $24,658,706 |
| 22 | Buried | EN | $1,044,143 | $19,439,764 |
| 23 | Mother | ES | $551,509 | $17,271,439 |
| 24 | Dark World |  RU | - | $16,976,423 |
| 25 | The Incite Mill | JP | - | $15,219,610 |
| 26 | Hunting Season |  TR | - | $12,571,431 |
| 27 | Get Low | EN | $9,176,933 | $10,522,511 |
| 28 | Ghost | JP | - | $9,833,553 |
| 29 | No Mercy | KR | - | $7,282,606 |
| 30 | Parallel Life | KR | - | $5,976,223 |
| 31 | The Voice | TR | - | $2,545,050 |
| 32 | All Good Things | EN | $582,024 | $1,754,389 |
| 33 | Triple Tap | - | $1,533,527 | |
| 34 | The Valdemar Legacy | ES | - | $1,493,227 |
| 35 | Priest of Evil |  FI | - | $965,827 |
| 36 | The Chasing World 2 | JP | - | $845,286 |
| 37 | Federal |  PT | - | $568,819 |
| 38 | Haunted Changi | EN | - | $519,733 |
| 39 | The Valdemar Legacy II: The Forbidden Shadow | ES | - | $348,272 |
| 40 | Dead Awake | EN | - | $318,275 |
| 41 | Needle | EN | - | $259,185 |
| 42 | Road to Nowhere | EN | $40,294 | $161,619 |
| 43 | The Weather Station | RU | - | $132,405 |
| 44 | The Haunted House Project | KR | - | $83,322 |
| 45 | Iron Doors |  DE | - | $38,457 |
| 46 | Sennentuntschi: Curse of the Alps | DE | - | $34,991 |
| 47 | Pulsar | EN | - | $29,825 |
| 48 | Beneath the Dark | EN | - | $23,998 |
| 49 | Bloody Innocent | KR | - | $15,621 |
| 50 | The Two Escobars | EN | $14,457 | $14,457 |
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