Top Grossing Drama Movies in Week 45 of 2010
| Rank | Title | Language | Domestic | Worldwide |
|---|---|---|---|---|
| 1 | Love & Other Drugs |  EN | $32,367,005 | $102,820,008 |
| 2 | 127 Hours | EN | $18,335,230 | $60,738,797 |
| 3 | For Colored Girls | EN | $37,729,698 | $37,981,984 |
| 4 | Fair Game | EN | $9,540,691 | $25,806,953 |
| 5 | Four Lions | EN | $304,616 | $6,149,356 |
| 6 | Action Replayy |  IN | - | $5,702,135 |
| 7 | Fortress of War |  RU | - | $4,569,604 |
| 8 | Outside the Law |  FR | $96,933 | $3,470,487 |
| 9 | A Quiet Life |  IT | - | $2,135,121 |
| 10 | Golmaal 3 | IN | $1,132,192 | $2,067,671 |
| 11 | Flying Pigs |  PL | - | $1,898,456 |
| 12 | The Coming Days |  DE | - | $492,376 |
| 13 | No Doubt |  KR | - | $394,485 |
| 14 | Lock Up |  ES | - | $288,197 |
| 15 | Rolling Home with a Bull | KR | - | $90,171 |
| 16 | Apnea |  EL | - | $1,547 |
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