Top Grossing Comedy Movies in May 2010
| Rank | Title | Language | Domestic | Worldwide |
|---|---|---|---|---|
| 1 | Shrek Forever After |  EN | $238,736,787 | $752,600,867 |
| 2 | Sex and the City 2 | EN | $95,347,692 | $290,745,055 |
| 3 | Letters to Juliet | EN | $53,032,453 | $79,293,444 |
| 4 | OSS 117 - Lost in Rio |  FR | $89,375 | $21,924,245 |
| 5 | Just Wright | EN | $21,540,363 | $21,584,424 |
| 6 | Micmacs | FR | $1,262,079 | $16,979,882 |
| 7 | Win/Win | EN | $10,179,275 | $11,789,613 |
| 8 | Looking for Eric | EN | $55,804 | $11,650,726 |
| 9 | MacGruber | EN | $8,525,600 | $9,322,895 |
| 10 | Hanni & Nanni |  DE | - | $7,151,391 |
| 11 | Solitary Man | EN | $4,360,548 | $5,682,554 |
| 12 | Schuks Tshabalala’s Survival Guide to South Africa | EN | - | $5,194,418 |
| 13 | The Infidel | EN | - | $2,817,080 |
| 14 | Abel |  ES | - | $2,706,679 |
| 15 | You to Me Are Everything | EN | - | $2,203,119 |
| 16 | Regresa | ES | - | $1,461,942 |
| 17 | Zebraman 2: Attack on Zebra City |  JP | - | $1,270,219 |
| 18 | The Best Things in the World |  PT | - | $1,220,116 |
| 19 | The Two Deaths of Quincas Wateryell | PT | - | $1,212,639 |
| 20 | Once a Gangster | - | $1,052,022 | |
| 21 | Sam Yan |  TH | - | $793,905 |
| 22 | Habana Eva | ES | - | $707,988 |
| 23 | Campamento Flipy | ES | - | $531,355 |
| 24 | Permanent Nobara | JP | - | $321,914 |
| 25 | A Distant Neighborhood | FR | - | $231,820 |
| 26 | Fenomen |  PL | - | $217,193 |
| 27 | I Am Kalam |  IN | - | $193,593 |
| 28 | Sin Sisters 2 | TH | - | $188,451 |
| 29 | Perrier's Bounty | EN | $828 | $167,938 |
| 30 | Here and There |  PH | $27,156 | $52,307 |
| 31 | Hello! How Are You? |  RO | - | $41,527 |
| 32 | Daddy Longlegs | $21,766 | $33,217 | |
| 33 | The Child Prodigy | FR | - | $23,927 |
| 34 | Zenitram | ES | - | $20,600 |
| 35 | The Lightkeepers | EN | - | $13,567 |
| 36 | All About Evil | EN | $7,995 | $7,995 |
| 37 | Bittersweet |  AR | - | - |
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