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Plot summary & ending explained

Inferno (2016) Plot Summary, Ending Explained & Timeline

Inferno (2016) movie poster

Inferno is a 2016 action and adventure film directed by Ron Howard, running 2 hours 1 minute. This page retells the whole story in 739 words (about 3 minutes to read) and covers 14 key events in order, 4 characters, where and when it is set, 3 themes and the ending explained. Looking for the cast, ratings and where to stream it? See the movie page for Inferno.

to read the plot summary
3 min
key events in the timeline
14
characters profiled
4
themes explained
3
Inferno (2016) movie poster
Released
Runtime
2h 1m
Director
Ron Howard
Original language
English
No spoilers

What Is Inferno About?

The premise of Inferno in 272 words, with nothing given away. The full story and the ending follow below.

In the luminous streets of Florence, a renowned scholar awakens with no memory of how he arrived, his mind a blank canvas punctuated only by a haunting sense of urgency. The city’s timeless art and narrow alleys become a confusing backdrop for a man whose expertise in symbols and history is now turned inward, as he struggles to piece together the fragments of his own past while the world outside seems poised on the brink of disaster.

Enter Dr. Sienna Brooks, a brilliant and resourceful physician who becomes his reluctant ally. Their partnership blends Langdon’s scholarly curiosity with Sienna’s pragmatic precision, creating a dynamic where intellectual puzzles are met with swift, decisive action. Together they navigate a fragile trust, each pushing the other to confront the unknown while the clock ticks inexorably onward.

Guided by cryptic clues drawn from Dante’s Inferno, the duo embarks on a cerebral chase that carries them across Europe’s most iconic landscapes—from the vaulted galleries of Venice to the shadowed corridors of ancient churches. The clues, steeped in literary and artistic references, transform the continent itself into a sprawling enigma, demanding both keen observation and bold intuition. The atmosphere remains taut, a blend of high‑brow intrigue and pulse‑quickening danger that keeps the stakes perpetually high.

Amidst the breathtaking scenery and the ever‑present threat of a looming catastrophe, the story balances the thrill of a race against time with a deeper meditation on memory, faith, and the power of symbols. It is a tense, atmospheric journey that asks whether a mind trained to decode the world’s mysteries can also reclaim its own lost narrative before it is too late.

Full plot

What Happens in Inferno?

The complete story of Inferno, from the first scene to the last, in 739 words (about 3 minutes). Spoilers throughout. Names in the text link to 3 cast member pages.

Spoilers ahead

Harvard University professor Robert Langdon finds himself awakening in a hospital room located in the enchanting city of Florence, Italy. However, he’s confronted with a fog of amnesia, unable to recollect the events that led him there. Instead, his mind is haunted by vivid visions of a devastated Earth. Among the medical staff is Dr. Sienna Brooks, who explains that his amnesia stems from a bullet wound to his head. Just as they discuss his situation, the police arrive to question Langdon, but in a shocking twist, the officer turns out to be Vayentha, an assassin portrayed by Ana Ularu, who murders the doctor and forces Langdon and Sienna to flee to her apartment in order to dodge danger.

In the chaos, they discover a “Faraday pointer” hidden among Langdon’s personal items, a small projector displaying a modified rendition of Sandro Botticelli’s Map of Hell, inspired by Dante’s Inferno. This revelation marks the beginning of a perilous quest, unveiling a trail left by the enigmatic Bertrand Zobrist, played by [Ben Foster]. Zobrist, a billionaire geneticist, held a controversial belief in the necessity of drastic measures to curb the world’s escalating population, leading to his own suicide as he evaded armed government agents.

As Langdon and Sienna delve deeper into the mystery, they uncover Zobrist’s obsession with Dante. He has engineered a lethal virus he dubbed “Inferno,” which threatens to wipe out a significant portion of humanity. All the while, both Vayentha and the World Health Organization (WHO) are hot on their heels, forcing the duo into a series of narrow escapes. Though Langdon has no recollection of meeting Zobrist, Sienna suspects that the first clue left for Langdon is linked to the virus, compelling them to decipher hidden passages and littered clues across Florence and Venice.

As they navigate this deadly game of cat and mouse, Langdon comes to realize his own past actions and those related to the elusive Dante Death Mask, a crucial key in untangling the web of deceit and danger surrounding them. During one harrowing encounter, Vayentha confronts Langdon, declaring he was once deemed “required,” but now was acting “stupid,” which has spurred her employers to eliminate him. However, Sienna intervenes, and in a tense moment, she kills Vayentha.

Vayentha’s superior, Harry Sims, the CEO of a private security firm known as “The Consortium,” is working not only for Zobrist but also for his own interests. Meanwhile, the WHO, led by Elizabeth Sinskey, an old flame of Langdon’s, tries to avert a global crisis and thwart the release of the virus. Despite all efforts, Zobrist’s pre-recorded message exposing his plans is about to unfold after 24 hours following his death. Driven by shock at the video’s content, Sims chooses to ally with Sinskey to halt the impending threat, revealing that Zobrist had tasked his organization with concealing the operation from the WHO.

The chase intensifies as Langdon is pulled deeper into a treacherous puzzle leading to Dante’s Death Mask, nestled within a church in Florence. When they encounter Christoph Bouchard, who claims to be working for the WHO, warning them of Sinskey’s potential double intentions, they initially unite but quickly realize Bouchard harbors his own ulterior motives, prompting them to escape once more.

Langdon soon deduces that the virus is concealed within the Hagia Sophia in Istanbul. In a shocking betrayal, Sienna reveals her true allegiance as Zobrist’s lover, committed to ensuring the virus’s release. The high-stakes treasure hunt, ironically reminiscent of games she played with Zobrist, has transformed into a deadly race against time. After a twist of fate, Langdon is captured but subsequently rescued by Sims, who has switched sides and now seeks to join forces with Sinskey for the greater good.

As they race against time, they discover the virus is hidden in a plastic bag submerged within the Basilica Cistern in Istanbul. In a climactic showdown, the WHO team, accompanied by Langdon, Sims, and Sinskey, rushes to secure it while Sienna begins orchestrating a catastrophic explosion aimed at dispersing the virus. Tragedy strikes when Sims is killed by Sienna, and in the final confrontation, she takes her own life in a desperate bid to unleash the virus. Fortunately, the team manages to secure the bag before disaster strikes, and the virus is confiscated by the WHO. Ultimately, Langdon returns to Florence, determined to restore the Dante Death Mask, marking the end of a harrowing journey intertwined with memory, betrayal, and salvation.

Timeline

Inferno Timeline: Every Key Event in Order

14 key events in the order they happen, from “Robert Langdon Awakens” to “Langdon's Return to Florence”. 8 events name a place, across 6 locations.

  1. 1

    Robert Langdon Awakens

    Professor Robert Langdon awakens in a hospital room in Florence, Italy, with no recollection of how he arrived there. He is confronted by the shocking reality of his amnesia, stemming from a bullet wound in his head.

    Where:Florence, Italy

  2. 2

    Dr. Sienna Brooks' Introduction

    Dr. Sienna Brooks, a medical professional in charge of Langdon's care, explains his condition and the circumstances surrounding his injuries. As they discuss his situation, their conversation is abruptly interrupted by the arrival of the police.

    Where:Hospital, Florence

  3. 3

    Assassin's Attack

    A police officer, later revealed to be an assassin named Vayentha, arrives and murders Dr. Brooks in front of Langdon. This shocking act forces Langdon and Sienna to flee the hospital to avoid becoming the next victims.

    Where:Hospital, Florence

  4. 4

    Discovery of the Faraday Pointer

    While hiding in Sienna's apartment, Langdon discovers a 'Faraday pointer' among his belongings. This small projector displays a modified image of Botticelli's *Map of Hell*, initiating their quest to unravel the mystery left by Bertrand Zobrist.

    Where:Sienna's Apartment, Florence

  5. 5

    Zobrist's Obsession with Dante

    As Langdon and Sienna investigate, they learn about Zobrist's controversial beliefs surrounding population control, leading to his own suicide. His obsession with Dante becomes the key to understanding the lethal virus he created.

  6. 6

    The Race Against Time Begins

    With the World Health Organization hot on their heels, Langdon and Sienna must decipher clues scattered across Florence and Venice. This deadly game intensifies as they desperately try to uncover the location of Zobrist's virus.

    Where:Florence and Venice

  7. 7

    A Confrontation with Vayentha

    The stakes rise when Vayentha confronts Langdon, revealing that he was once considered essential but has now become a target. In a moment of danger, Sienna steps in and kills Vayentha, further complicating their escape.

  8. 8

    Harry Sims' Involvement

    Harry Sims, the CEO of The Consortium, enters the fray as both an ally and a manipulator with his own agenda. His alignment with Sinskey reveals an unwelcome connection to Zobrist's plan designed to disrupt the WHO's efforts.

  9. 9

    Unraveling Betrayals

    Amidst the chaos, Langdon encounters Christoph Bouchard, who initially presents himself as a trustworthy participant in their quest. However, they soon discover that he has ulterior motives, leading to their hasty exit again.

  10. 10

    Location of the Virus Revealed

    Langdon deduces that the virus is hidden within the Hagia Sophia in Istanbul. Just as they begin to devise a plan, Sienna shocks Langdon by revealing her true allegiance as Zobrist's partner, complicating their mission.

    Where:Hagia Sophia, Istanbul

Show the other 4 events of Inferno
  1. 11

    High-Stakes Showdown

    As the urgency escalates, Langdon, Sims, and Sinskey rush to locate the virus within the Basilica Cistern in Istanbul. Their mission takes a hit when Sienna plans a catastrophic explosion to release the virus, raising the stakes immensely.

    Where:Basilica Cistern, Istanbul

  2. 12

    Tragedy Strikes

    The climax reaches a breaking point when Sienna kills Sims amidst the chaos during the final confrontation. In a heart-wrenching moment of realization and despair, Sienna takes her own life, attempting to ensure the virus's release.

  3. 13

    The WHO Secures the Virus

    Against all odds, the WHO team manages to recover the virus just before it can be unleashed. The critical moment is a victory over despair, showcasing the rapid evolution of trust and betrayal among the characters involved.

  4. 14

    Langdon's Return to Florence

    In the aftermath of the harrowing journey, Langdon returns to Florence with a newfound determination to restore the Dante Death Mask. His experience has reshaped him, intermingling themes of memory, betrayal, and ultimately, salvation.

    Where:Florence, Italy

Characters

Who Are the Main Characters in Inferno?

4 characters, among them Robert Langdon (played by Tom Hanks), Dr. Sienna Brooks (played by Felicity Jones) and Bertrand Zobrist (played by Ben Foster): who each one is and the part they play in the story. Every profile links to the actor’s page.

  • Tom Hanks as Robert Langdon (played by Tom Hanks) in Inferno

    Robert Langdon (played by Tom Hanks)

    Played by Tom Hanks

    Robert Langdon is a Harvard professor specializing in symbology and religious iconology. Throughout the film, he grapples with amnesia, which adds layers to his character as he embarks on a quest to recover his lost memories while simultaneously preventing a global disaster. Langdon's intellect and resourcefulness shine through, especially as he navigates complex puzzles and moral quandaries.

    • 🧠 Intelligent
    • 📚 Scholar
    • 🔍 Investigator
  • Felicity Jones as Dr. Sienna Brooks (played by Felicity Jones) in Inferno

    Dr. Sienna Brooks (played by Felicity Jones)

    Played by Felicity Jones

    Sienna Brooks appears as a capable and resourceful doctor who assists Langdon. However, her true allegiance is shrouded in mystery, adding complexity to her character. Sienna’s motivations become clear as the story unfolds, embodying the themes of betrayal and moral conflict.

    • 💉 Doctor
    • 🏃‍♀️ Resourceful
    • 🌪️ Torn
  • Ben Foster as Bertrand Zobrist (played by Ben Foster) in Inferno

    Bertrand Zobrist (played by Ben Foster)

    Played by Ben Foster

    Bertrand Zobrist is portrayed as a brilliant but controversial billionaire whose radical ideology on overpopulation leads him to drastic actions. His character drives the plot, as his legacy of chaos and his engineering of the 'Inferno' virus uncover themes of morality and the consequences of one's beliefs.

    • 🔬 Genius
    • ♟️ Manipulative
    • 💔 Tragic
  • Irrfan Khan as Harry Sims (played by Irrfan Khan) in Inferno

    Harry Sims (played by Irrfan Khan)

    Played by Irrfan Khan

    Harry Sims is the CEO of a private security firm who plays a pivotal role in the conflict. Initially aligned with Zobrist, Sims' shift in allegiance reflects a deeper commitment to preventing disaster. His character adds a layer of intrigue and depth as he navigates corporate and personal motives.

    • 💼 Corporate
    • ⚖️ Duality
    • 🕵️‍♂️ Strategic
Setting

Where and When Is Inferno Set?

Inferno is set in Florence, Venice and Istanbul. Here is why the place matters to the story.

When

The time period is contemporary, reflecting modern global concerns such as overpopulation and bioethics. The narrative intertwines historical references, specifically the works of Dante Alighieri, with modern threats, creating a bridge between the past and present.

Where

Florence, Venice, Istanbul

The movie takes place in iconic cities known for their rich history and art. Florence, Italy, is known for its Renaissance art and architecture, including the Uffizi Gallery and the Florence Cathedral. Venice, with its labyrinth of canals, contributes to the chase's intrigue, while Istanbul, steeped in history, hides crucial secrets within its famous landmarks like the Hagia Sophia.

  • 🏛️ Historical
  • 🌍 Global
  • 🌆 Cityscape
Themes

What Are the Themes of Inferno?

3 ideas the story keeps returning to, among them Betrayal, Mystery and Global Crisis.

  1. 01

    Betrayal

    Betrayal is a central theme as characters shift allegiances throughout the story. Sienna's ultimate betrayal against Langdon not only adds tension but also underscores the tragic consequences of misplaced trust. The web of deceit reveals deeper layers of interpersonal relationships amidst a high-stakes conflict.

  2. 02

    Mystery

    Mystery permeates the plot as the characters decipher clues left by the deceased billionaire Bertrand Zobrist. From hidden projections to ancient artifacts, each revelation brings them closer to the truth about the 'Inferno' virus and its implications. The constant unraveling of secrets keeps viewers on the edge of their seats.

  3. 03

    Global Crisis

    The theme of a global crisis is prevalent due to the impending threat posed by the lethal virus engineered by Zobrist. The characters' race against time to prevent potential catastrophe highlights the moral dilemmas surrounding population control and the ethics of extreme solutions for societal issues.

Ending explained

How Does Inferno End?

The last act of Inferno and what it means, in 254 words. The ending lands as happy. Big spoilers: read the plot summary first if you have not seen it.

The final act, in full

The ending of Inferno resolves the frantic chase across Europe with a decisive confrontation that clarifies the allegiances Robert Langdon has been questioning throughout the film. After piecing together the clues hidden within Dante’s history and overcoming his amnesia, Langdon discovers that Sienna Brooks, the doctor who seemingly aided his escape, was actually a secret adherent to Bertrand Zobrist’s cause. While the film builds tension around a virus designed to decimate the global population, the climax reveals that Langdon and the World Health Organization successfully intervene. They locate the containment unit in Istanbul before it can rupture, and the immediate threat of the “Inferno” plague is neutralized, allowing Langdon to return the poetic mask to its rightful place and ending the immediate crisis.

However, the resolution goes beyond simply stopping a biological weapon; it emphasizes the philosophical weight of the story. Zobrist’s plan is thwarted, but the film leaves the audience to wrestle with the validity of his terrifying question regarding overpopulation. As Ben Foster noted in discussing the character, Zobrist’s motivation was born of a grim perspective on the future, arguing that humanity must take “personal responsibility” for its survival. By preventing the mass culling, the protagonists choose a path of hope, yet the narrative underscores the urgency of the actors’ shared sentiment: that we must all do our part to address global challenges before extreme measures become the only options left. The ending is not just a victory for Langdon, but a challenge to the viewer to consider the cost of inaction.

Tone & mood

What Kind of Film Is Inferno?

Tense in tone, with fast pacing and a complex story, going by the plot summary.

Tone
Tense
Pacing
Fast
Story
Complex
Intensity
High
Ending
Happy

A relentlessly fast-paced and tense thriller that plunges the viewer into a high-stakes race to prevent a global catastrophe, marked by constant danger, shocking betrayals, and frantic puzzle-solving across Europe.

  • anxious
  • relentless
  • paranoid
  • urgent
  • dangerous
  • suspenseful
  • race against time
  • conspiracy
  • global pandemic
  • code breaking

Content notes: assassination, suicide, genocidal plot, biological weapon.

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Where to watch

Where to Watch Inferno

Stream it on MovieSphere+ and Netflix, or rent or buy it from Amazon Video and Apple TV Store. US availability and prices from JustWatch.

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FAQ

Inferno Plot Questions

6 quick answers about Inferno, taken from the plot summary, ending explained, character guide and setting on this page and the film’s credits.

What is Inferno about?

In the luminous streets of Florence, a renowned scholar awakens with no memory of how he arrived, his mind a blank canvas punctuated only by a haunting sense of urgency.

Read the full plot summary

What happens at the end of Inferno?

The ending of Inferno resolves the frantic chase across Europe with a decisive confrontation that clarifies the allegiances Robert Langdon has been questioning throughout the film.

The ending explained

When and where does Inferno take place?

Inferno is set in Florence, Venice and Istanbul. The time period is contemporary, reflecting modern global concerns such as overpopulation and bioethics. The narrative intertwines historical references, specifically the works of Dante Alighieri, with modern threats…

The setting explained

Who are the main characters in Inferno?

The story follows Robert Langdon (played by Tom Hanks) (played by Tom Hanks), Dr. Sienna Brooks (played by Felicity Jones) (played by Felicity Jones), Bertrand Zobrist (played by Ben Foster) (played by Ben Foster) and Harry Sims (played by Irrfan Khan) (played by Irrfan Khan).

All the characters

What are the main themes of Inferno?

The summary picks out 3 themes: Betrayal, Mystery and Global Crisis.

The themes explained

Who directed Inferno?

Inferno (2016) was directed by Ron Howard and runs 2 hours 1 minute.

Ron Howard’s films

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