Top Grossing Comedy Movies in December 1980
| Rank | Title | Language | Domestic | Worldwide |
|---|---|---|---|---|
| 1 | 9 to 5 |  EN | $103,290,500 | $103,303,473 |
| 2 | Stir Crazy | EN | $101,300,000 | $101,300,000 |
| 3 | Any Which Way You Can | EN | $70,687,344 | $70,687,344 |
| 4 | Popeye | EN | $49,823,037 | $49,823,329 |
| 5 | Seems Like Old Times | EN | $43,995,918 | $43,995,918 |
| 6 | First Family | EN | $15,198,912 | $15,198,912 |
| 7 | Tribute | EN | $9,000,000 | $9,000,000 |
| 8 | La Cage aux Folles II |  FR | $6,950,125 | $6,950,125 |
| 9 | A Change of Seasons | EN | - | - |
| 10 | Inside Moves | EN | - | - |
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