South Park: Post COVID: The Return of COVID 2021

Kyle is principled, intelligent, and quick to reason under pressure. He resists Chaos's manipulation, helps drive the time-travel plan, and eventually becomes a father of two in the revised timeline.

Cartman is manipulative and self-serving, forming the Foundation Against Time Travel to push his own agenda. He aims to kill Kyle in the past, but the plan is thwarted; in the revised future he is homeless and bitter.

Kenny quietly drives a strategy to salvage the boys' friendship rather than merely prevent the pandemic. His role highlights his loyalty and the value of lasting bonds over radical changes.

Tweek teams with Craig to retrieve aluminum foil for the plan. Their dynamic adds humor and loyalty as they navigate the dangerous scheme.

Craig accompanies Tweek in the foil quest and shares in the group's misadventures. He remains a grounded, supportive ally as events unfold.

Wendy is Stan's ally and confidant, helping to reveal crucial information and guide decisions. She steadfastly supports her friends and faces the consequences of their schemes.

Sharon is Stan's mother, a figure connected to the family drama and the consequences of past actions. In the revised timeline, she remains a protective parent and a survivor.

Shelley is Stan's sister who experiences the broader implications of the timeline shifts. She remains part of the family unit in the revised future.

Heather is the target of a blackmail scheme to secure Nuggets tickets, a catalyst for the events in the present timeline. Her presence exposes manipulation and the consequences of fame-seeking actions.

Yentl is Cartman's wife, providing a stabilizing counterpoint that nudges Cartman toward a more collaborative course of action when the plan unfolds.

Menorah Cartman is Cartman's partner, further illustrating the family dimension of Cartman's life in the later timeline.

Token is a capable ally who participates in defending Randy and aiding the group's mission. He plays a decisive role in overcoming the nurses at Shady Acres.

Chaos is the insane persona adopted by Butters Stotch, who has turned to NFTs and brainwashing as part of his isolation. He escapes and remains a wildcard in the story.