Someone’s Knocking at the Door 2009

Ray Harris [Jordan Lawson], a med student, spends a night in his dorm watching stag films and testing what he thinks is heroin, only to discover it’s an experimental drug called Taldon. A knock on the door brings a shocking encounter: a fully nude woman who makes advances, then morphs into a grotesque man. The man assaults Ray, and it’s strongly implied that he rapes and kills him.

Ray’s friends Meg [Andrea Renda], Joe [Ricardo Gray], and Annie [Silvia Spross] learn of his death. Another friend, Sebastian Wilde [Jon Budinoff], suspects Joe of killing Ray in a bizarre sex game, since Joe was the last person seen with Ray. Justin [Noah Segan] joins them at Ray’s funeral. Meanwhile, the police are baffled to learn that Ray died after a phallus—fifteen inches long and four inches in diameter—pummeled his colon. The five remaining students come under suspicion, but no solid evidence ties them to the crime and they are allowed to leave.

A flashback shows the six friends revisiting Taldon and studying the case files of John Hopper [Ezra Buzzington] and Wilma Hopper [Elina Madison], a serial killer couple once the subject of a hospital study. They speculate that the Hoppers, long thought dead, may have returned via astral projection.

Sebastian and Annie park in a secluded woods to make out. Annie grows frustrated with Sebastian’s aggressive behavior and is soon confronted by the demonic Wilma Hopper, who uses her power to suffocate Annie. Back at the hospital, a detective reading about the Hopper case is attacked by the reanimated John Hopper, who forces the detective to perform a sexual act.

Meg, after a romantic evening with Justin, dives into research on Taldon. She learns that the drug is a hallucinogen that drives the central nervous system to dangerous extremes. Her work is interrupted when the same undead detective from the hospital confronts her in the corridors, and she narrowly escapes.

John Hopper, taking on Annie’s form, seduces and kills Sebastian through a brutal sexual assault. Meg lies wounded in a hospital bed, while Justin—still alive—rejoins her. He believes himself trapped in an artificial reality and shoots Joe and another detective before taking his own life. The sequence culminates in a devastating twist: all of the events are Justin’s dying hallucination, spawned after he and his friends overdosed on Taldon the night they first read about the Hopper spree. It’s initially believed that Justin perished with his friends (Meg aside, who had sworn off drugs), but he somehow survives.