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This inventive film combines animation and live-action storytelling, following the journey of Osmosis Jones, a dedicated white blood cell, and his efforts to combat a dangerous virus. When the illness threatens Frank, the human host played by Bill Murray, Osmosis must embark on a thrilling and comedic mission to save him. Chris Rock lends his voice to the courageous Osmosis in this action-packed comedy-adventure.

This inventive film combines animation and live-action storytelling, following the journey of Osmosis Jones, a dedicated white blood cell, and his efforts to combat a dangerous virus. When the illness threatens Frank, the human host played by Bill Murray, Osmosis must embark on a thrilling and comedic mission to save him. Chris Rock lends his voice to the courageous Osmosis in this action-packed comedy-adventure.

Does Osmosis Jones have end credit scenes?

No!

Osmosis Jones does not have end credit scenes. You can leave when the credits roll.

Meet the Full Cast and Actors of Osmosis Jones

Explore the complete cast of Osmosis Jones, including both lead and supporting actors. Learn who plays each character, discover their past roles and achievements, and find out what makes this ensemble cast stand out in the world of film and television.


Ratings and Reviews for Osmosis Jones

See how Osmosis Jones is rated across major platforms like IMDb, Metacritic, and TMDb. Compare audience scores and critic reviews to understand where Osmosis Jones stands among top-rated movies in its genre.


Metacritic

57

Metascore

6.2

User Score

Rotten Tomatoes
review

55%

TOMATOMETER

review

42%

User Score

IMDb

6.3 /10

IMDb Rating

TMDB

65

%

User Score

Take the Ultimate Osmosis Jones Movie Quiz

Challenge your knowledge of Osmosis Jones with this fun and interactive movie quiz. Test yourself on key plot points, iconic characters, hidden details, and memorable moments to see how well you really know the film.


Osmosis Jones Quiz: Test your knowledge on the animated film Osmosis Jones and its unique take on the human body.

Who is the main character that represents a white blood cell in the film?

Awards & Nominations for Osmosis Jones

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Discover all the awards and nominations received by Osmosis Jones, from Oscars to film festival honors. Learn how Osmosis Jones and its cast and crew have been recognized by critics and the industry alike.


29th Annual Annie Awards 2001

Nomination

Best Animated Feature

Full Plot Summary and Ending Explained for Osmosis Jones

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Read the complete plot summary of Osmosis Jones, including all major events, twists, and the full ending explained in detail. Explore key characters, themes, hidden meanings, and everything you need to understand the story from beginning to end.


Frank Detorre, a slovenly widower and zookeeper at the Sucat Memorial Zoo in Rhode Island, leads a life filled with unhealthy habits that exasperate his young daughter, Shane. He eats compulsively and shows little regard for germs or hygiene. During one particularly grotesque meal involving a hard-boiled egg smeared with mayonnaise and salt, Frank is thwarted by a mischievous chimpanzee that snatches the egg away. Although he retrieves it, it meets a grim fate in the mess of the chimp’s habitat. When Shane expresses her disgust at her father’s unsanitary snack, Frank shamelessly defends his actions with the infamous > “ten second rule.”

Within Frank’s body, Osmosis “Ozzy” Jones, a witty and adventurous white blood cell, finds himself on an unconventional mission. This rebellious agent of the Frank PD often disregards protocol in pursuit of what he believes is right, earning him the scorn of his fellow cells. After an embarrassing incident where he inadvertently makes Frank vomit all over Shane’s science teacher, Mrs. Boyd, at the science fair—under the mistaken belief that a raw oyster posed a threat—Ozzy is reassigned to the mouth to combat germs.

The body soon becomes a battleground when newcomer germs hijack a squad car inside Frank’s mouth, prompting an action-packed chase that climaxes with a massive yawn pulling Ozzy and his partner, the cold-suppressant pill Drix (Drixenol “Drix” Koldreliff), into the lungs. Although ordered to stand down, Ozzy defies orders in a pursuit that inadvertently triggers a cramp in Frank’s leg. Meanwhile, Mayor Phlegmming faces re-election, promising junk food despite it being one of the factors behind Frank’s declining health.

As if the situation wasn’t dire enough, a lethal virus known as Thrax emerges, having hitchhiked along with Frank’s hard-boiled egg. Determined to downplay the emergency, Phlegmming instructs Frank to take the Drix pill, which arrives to quell the irritation in Frank’s throat. As Ozzy begrudgingly partners with Drix, they learn from a common influenza virus about Thrax’s sinister plan to masquerade as a harmless cold while plotting Frank’s demise through a fever.

The tense confrontation ensues in one of Frank’s zits, where Drix detonates a grenade of medicine, effectively popping the blemish and annihilating nearly all of Thrax’s minions. However, Thrax survives the explosion and attacks Frank’s hypothalamus, diminishing its ability to self-regulate and stealing critical DNA. Chaos erupts as Frank’s body temperature escalates dangerously, necessitating an emergency trip to the hospital just as Ozzy and Drix embark on a rescue mission for Leah Estrogen, the mayor’s secretary, who has been taken hostage by Thrax.

A gripping showdown occurs on one of Shane’s eyeballs, where Ozzy intervenes just in time to save her from Thrax’s lethal intentions, ultimately causing Thrax to meet his end in a vessel of alcohol below. Meanwhile, the internal crisis reaches a fever pitch, pushing Frank into cardiac arrest as the doctors seem ready to concede defeat. In a moment of salvation, Ozzy returns to Frank’s body with a tear from Shane, which contains the missing hypothalamus chromosome, bringing Frank back to life.

Reinstated in “Immunity” with newfound accolades, Ozzy and Drix emerge as heroes, while Frank begins to turn his life around, looking after his health and hygiene with renewed determination. In an ironic twist, Mayor Phlegmming faces a fall from grace, finding himself reduced to the role of a janitor in the bowels, where he accidentally ejects himself by triggering a forbidden button that sets off Frank’s farting.

Uncover the Details: Timeline, Characters, Themes, and Beyond!

Watch Trailers, Clips & Behind-the-Scenes for Osmosis Jones

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Watch official trailers, exclusive clips, cast interviews, and behind-the-scenes footage from Osmosis Jones. Dive deeper into the making of the film, its standout moments, and key production insights.


Osmosis Jones Trailer 1 (2001)

Osmosis Jones

Cars Featured in Osmosis Jones

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Explore all cars featured in Osmosis Jones, including their makes, models, scenes they appear in, and their significance to the plot. A must-read for car enthusiasts and movie buffs alike.


BMW

1996

3 Coupé E36

Cadillac

1996

Seville STS

Chevrolet

1999

Silverado

Chrysler

1994

LHS

Chrysler

1996

Town & Country

Ford

1992

Crown Victoria

Ford

1991

Explorer

Ford

1984

LTD Crown Victoria

Ford

1993

Taurus

GM

EV1

Movie Themes and Keywords

Discover the central themes, ideas, and keywords that define the movie’s story, tone, and message. Analyze the film’s deeper meanings, genre influences, and recurring concepts.


white blood celltwo word titleclose up of eyewisecrack humorcancerelasticityfictional drugfictional citypillstupiditydumb policecomic reliefnanopunkbiopunklymph nodelive action animated hybridlive action and animationcrashslapstick comedysingingslimehousealtered version of studio logogross out comedyanthropomorphismcity2d animationhand drawn animationtraditional animation2000scgi effectlive action animationtwo directorsstar died before releaseinside bodymicrophoneeyeglassesdancerainford crown victoriavolkswagenjeepcarrotjeep cherokeesunglassestablechairbaseball capeating a carrottoilethugging

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